Berna Sözen

The paper investigates how Lamin A/C influences chromatin structure during early mammalian lineage segregation, showing its role in maintaining trophectoderm identity.

The paper introduces iDiscoid, a human stem cell model of post-implantation development that recapitulates key morphogenetic features and offers a platform for studying early human development.

This study identifies how distinct glucose metabolic pathways guide spatial and temporal aspects of mouse gastrulation, linking metabolism to cell fate and morphogenesis.

This study uses human pluripotent stem cells to create an in vitro model of early human embryogenesis, recapitulating key developmental events from embryonic day 3 to day 9/10.

This study identifies the mechanism of first lineage segregation in human embryos through cell polarisation, showing it occurs at the 8-cell stage via F-actin and Par complex polarisation, with PLC activation and GATA3 regulation.