Meng Zhu

The paper identifies differential oxygen levels as a driver of heterochrony in limb development between avian and mammalian embryos.

The paper shows that asynchronous polarization in mouse embryos leads to heterogeneity in cell fate specification, linking early 4-cell stage asymmetries to later 8-cell stage lineage decisions.

This study reprograms non-limb fibroblasts into cells with limb progenitor properties using Prdm16, Zbtb16, Lin28, and Lin41.

This study uses human pluripotent stem cells to create an in vitro model of early human embryogenesis, recapitulating key developmental events from embryonic day 3 to day 9/10.

This study identifies transcriptional control and protein clustering as mechanisms driving cell polarity establishment in early mouse embryos.

This study identifies the mechanism of first lineage segregation in human embryos through cell polarisation, showing it occurs at the 8-cell stage via F-actin and Par complex polarisation, with PLC activation and GATA3 regulation.