Developmental BiologybioRxivPreprint
Mechanism of cell polarisation and first lineage segregation in the human embryo
Meng Zhu, Marta N. Shahbazi, Ángel Martín…·Magdalena Zernicka‐Goetz
This study identifies the mechanism of first lineage segregation in human embryos through cell polarisation, showing it occurs at the 8-cell stage via F-actin and Par complex polarisation, with PLC activation and GATA3 regulation.