Author

Brooke A. Scelza

University of California, Los AngelesORCID 0000-0001-5875-8875Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetics· 2 Bioinformatics· 1 Evolutionary Biology· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Organism:human· 5 Approach:statistical model· 4 Assay:whole-genome sequencing· 3 Research Focus:differential expression· 2 Assay:DNA methylation· 2 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Approach:machine learning (classical)· 1

Frequent Co-Authors

Brenna M. HenniD· 5 shared Sean P. PralliD· 3 shared Gillian L. MeeksiD· 2 shared Neus Font‐PorteriasiD· 2 shared Shyamalika GopalaniD· 2 shared Akmel N. Negash· 1 shared Alain FromentiD· 1 shared Alison N. KilliliaiD· 1 shared

Activity by Year

2023-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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5 shared papersGenetics

Brenna M. HennORCID

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Author profile →

5 papers

Recent·Most cited

Recurrent structural variation and recent turnover at the 17q21.31 locus in humans and great apes

Samvardhini Sridharan, Runyang Nicolas Lou, Scott Ferguson, Joana L. Rocha, Rishi De‐Kayne, Matthew W. Mitchell, Alison N. Killilia, CAAPA PopGen Working Group, Akmel N. Negash, Daniel Ansong, Sandra Kwarteng Owusu, André Garcia, Brooke A. Scelza, Marlo Möller, Caitlin Uren, , Peter H. Sudmant

The paper characterizes structural variation at the 17q21.31 locus in humans and great apes, identifying new haplotypes and evolutionary dynamics.

Nature Communications · May 19, 2026Peer-reviewedGenomics

A rapid, accurate approach to inferring pedigrees in endogamous populations

Cole M Williams, Brooke A. Scelza, Sarah Danielle Slack, Neus Font‐Porterias, Dana R. Al-Hindi, Rasika A. Mathias, Harold R. Watson, Kathleen C. Barnes, Ethan M. Lange, Randi K. Johnson, Christopher R. Gignoux, Sohini Ramachandran, Brenna M. Henn

This paper introduces a rapid algorithm for pedigree inference in endogamous populations, accurately distinguishing relationships and handling reticulations.

Genetics · May 20, 2025Peer-reviewedBioinformatics

No evidence for disassortative mating based on HLA in a small-scale, endogamous population

Gillian L. Meeks, Brooke A. Scelza, Katherine M. Kichula, Catrinel Berevoescu, Kristin Hardy, Ticiana D.J. Farias, Genelle F. Harrison, Nicholas R. Pollock, Neus Font‐Porterias, Sean P. Prall, Paul J. Norman, Brenna M. Henn

The paper tests HLA dissimilarity in Himba pastoralists and finds no evidence of disassortative mating or fitness benefits from HLA differences in either arranged or chosen partnerships.

bioRxiv · May 6, 2025 · PreprintEvolutionary Biology

Common DNA sequence variation influences epigenetic aging in African populations

Gillian L. Meeks, Brooke A. Scelza, Hana M. Asnake, Sean P. Prall, Étienne Patin, Alain Froment, Maud Fagny, Lluís Quintana‐Murci, Brenna M. Henn, Shyamalika Gopalan

The paper develops an epigenetic age predictor that accounts for DNA sequence variation in African populations, finding that genetic variants can influence epigenetic age and longevity.

bioRxiv · Aug 26, 2024 · PreprintGenetics

Increased homozygosity due to endogamy results in fitness consequences in a human population

Natalie Swinford, Sean P. Prall, Shyamalika Gopalan, C. M. Williams, Jacob Sheehama, Brooke A. Scelza, Brenna M. Henn

The paper examines the fitness consequences of increased homozygosity in the Himba population, finding a significant association between higher FROH and reduced fertility.

Proceedings of the National Academy of Sciences · Oct 17, 2023Peer-reviewedGenetics