Nicholas R. Pollock

Hybrid HiFi/ultra-long ONT assemblies of 65 diverse humans yield 130 haplotypes, 1,246 complete centromeres, and a pangenome panel enabling short-read genome inference at median QV 45.

The paper tests HLA dissimilarity in Himba pastoralists and finds no evidence of disassortative mating or fitness benefits from HLA differences in either arranged or chosen partnerships.

MHConstructor provides a haplotype-informed, high-throughput pipeline for de novo MHC assembly from short read data, improving upon reference-based methods.

The paper completes six MHC haplotypes, including DR1, DR4, and structurally variable C4 regions, improving reference panels for immunogenomics analysis.