This study presents a pan-pangenome of humans, chimpanzees, and bonobos, revealing structural variation, selection patterns, and adaptations related to immunity and malaria resistance.

bioRxiv · Jun 8, 2026 · PreprintEvolutionary Biology

A Multimodal Adaptive Optical Microscope For In Vivo Imaging from Molecules to Organisms

Tian-ming Fu B, Gaoxiang Liu, Daniel Edward Milkie, Xiongtao Ruan, Frederik Görlitz, Yu Shi, Valentina Ferro, Nikita S. Divekar, Wei Wang, Harrison M. York, Velat Kilic, Matthew Mueller, Yajie Liang, Timothy A. Daugird, María José Gacha Garay, , Srigokul Upadhyayula

The paper introduces MOSAIC, a multimodal adaptive optical microscope that enables non-invasive imaging across biological scales in live specimens.

Nature Methods · May 22, 2026Peer-reviewedCell Biology

Recurrent structural variation and recent turnover at the 17q21.31 locus in humans and great apes

Samvardhini Sridharan, Runyang Nicolas Lou, Scott Ferguson, Joana L. Rocha, Rishi De‐Kayne, Matthew W. Mitchell, Alison N. Killilia, CAAPA PopGen Working Group, Akmel N. Negash, Daniel Ansong, Sandra Kwarteng Owusu, André Garcia, Brooke A. Scelza, Marlo Möller, Caitlin Uren, , Peter H. Sudmant

The paper characterizes structural variation at the 17q21.31 locus in humans and great apes, identifying new haplotypes and evolutionary dynamics.

Nature Communications · May 19, 2026Peer-reviewedGenomics

Image processing tools for petabyte-scale light sheet microscopy data

Xiongtao Ruan, Matthew Mueller, Gaoxiang Liu, Frederik Görlitz, Tian-ming Fu B, Daniel Edward Milkie, Joshua L. Lillvis, Alexander Kühn, Johnny Gan Chong, Jason Li Hong, Chu Yi Aaron Herr, Wilmene Hercule, Marc Nienhaus, Alison N. Killilea, Eric Betzig, Srigokul Upadhyayula

The paper introduces PetaKit5D, a software solution for efficient processing of petabyte-scale light sheet microscopy data, achieving performance improvements over existing methods.

Nature Methods · Oct 17, 2024Peer-reviewedBioinformatics