Nathan K. Schaefer

The paper identifies human-specific gene regulation in telencephalic progenitors by analyzing morphogen-dependent gene expression responses across human, chimpanzee, and orangutan species.

CellBouncer demultiplexes and analyzes pooled single-cell data, revealing mitochondrial incompatibilities between humans and chimpanzees.

The paper identifies transcription factors and effector genes involved in human cortical neurogenesis using CRISPRi screening in a primary culture system.

The paper identifies human-specific deletions that affect gene expression by using CRISPRi screening in chimpanzee stem cells.

The paper analyzes genomic data from passenger pigeons and their relatives to show that natural selection reduced neutral genetic diversity despite large population size, challenging previous extinction theories.