Brandon R. Desousa

This study identifies branched-chain amino acid fermentation as an alternative electron sink in mammals under hypoxia, with implications for reductive stress and sperm motility.

This study identifies THAP12 as a transcriptional regulator of mitochondrial complex I biogenesis and shows its role in neurodevelopmental disorders.

This study shows that red blood cells act as a primary glucose sink under hypoxia, improving glucose tolerance and offering therapeutic potential for diabetes.

This study shows that reduced oxidative phosphorylation is not required for pro-inflammatory macrophage activation, challenging the conventional model of mitochondrial reprogramming.