Brandon T.L. Chew

This study identifies branched-chain amino acid fermentation as an alternative electron sink in mammals under hypoxia, with implications for reductive stress and sperm motility.

This study shows systemic hypoxia reduces solid tumor growth across multiple cancer types without resistance, through purine metabolism suppression and can be pharmacologically induced.

This study introduces RASAM, a method to analyze nascent chromatin structure, finding that newly replicated chromatin is hyperaccessible and has unique organization features.

The paper develops a combined chemical and immunoaffinity approach to profile protein methylation, identifying novel PRMT1 targets and revealing dynamic interactions between methyltransferases.