Isha H. Jain

This study identifies branched-chain amino acid fermentation as an alternative electron sink in mammals under hypoxia, with implications for reductive stress and sperm motility.

This study identifies THAP12 as a transcriptional regulator of mitochondrial complex I biogenesis and shows its role in neurodevelopmental disorders.

This study shows that red blood cells act as a primary glucose sink under hypoxia, improving glucose tolerance and offering therapeutic potential for diabetes.

This study shows systemic hypoxia reduces solid tumor growth across multiple cancer types without resistance, through purine metabolism suppression and can be pharmacologically induced.

The paper uses a CRISPRi screen to identify basigin loss as protective in cardiac hypoxia by enhancing ATP maintenance and survival.

The paper identifies genetic regulators of neuronal survival across different metabolic environments using CRISPRi screens in human neurons.

This study shows gut bacteria produce lactate that increases lung epithelial mitochondrial activity and worsens acute lung injury.

This study introduces RASAM, a method to analyze nascent chromatin structure, finding that newly replicated chromatin is hyperaccessible and has unique organization features.