ZDHHC17 Links S-Acylation, Huntington Disease, VCP-associated Multisystem Proteinopathy, and Amyotrophic Lateral Sclerosis.
Firyal Ramzan, Gyana Gourab Mishra, Yasmeen Alshehabi, Cailyn M. Perry, Lucia M. Q. Jadon, Ashish Kumar, Helen Kim, Ryan Christopher Uy, Anthony Dang, Muneera Fayyad, Raoul Ovalekar, Alicia F. Dubinski, Alyssa E. Johnson, Virginia E. Kimonis, Christine Vande Velde, , Dale D. O. Martin
This study identifies ZDHHC17 as a key enzyme linking S-acylation to neurodegenerative diseases by modulating protein localization and toxicity.
bioRxiv · Aug 3, 2026 · PreprintNeuroscience