Zhenyu Xuan

This study identifies miR-34/449 miRNAs as regulators of choroid plexus multiciliogenesis, showing their role in controlling cerebrospinal fluid production through modulation of Shh signaling.

GMIP-PLSR improves GWAS gene prioritization by integrating multi-omics data using PLSR to address multicollinearity, outperforming PoPS in NAFLD case studies.

The paper introduces Hi-GREx, a method using Hi-C data to select long-distance SNPs for improved gene expression prediction, outperforming traditional TWAS approaches.

This study shows that multicilia in the choroid plexus transduce non-canonical Shh signaling to regulate CSF production by repressing Aqp1 and Atp1a2 expression.

This study identifies Klf5 as a key regulator of bi-potential cell fate in mouse preimplantation embryos by controlling both ICM and TE specification genes.

The paper identifies a species-specific retrotransposon promoter that generates a conserved Cdk2ap1 isoform essential for preimplantation development across mammals.

This study shows that BRG1 phosphorylation, induced by neuronal activity, regulates enhancer activation and gene induction, affecting behavior and stress responses in mice.