Wanqing Shao

The paper investigates sex-specific molecular responses to early-life toxicant exposures in mice across multiple life stages using transcriptomic and epigenomic data.

This study uses exome sequencing to identify genetic associations with interstitial cystitis/bladder pain syndrome, finding new links and extending known associations.

The paper characterizes persistent epigenomic and transcriptomic changes in mice exposed to environmental toxicants across life stages, revealing widespread gene expression and chromatin alterations.

This study examines how early-life exposure to environmental toxicants alters TE chromatin accessibility and expression in mouse liver, revealing exposure-specific and sex-dependent effects.

This study evaluates the diagnostic yield of long-read sequencing in pediatric sensorineural hearing loss, finding it detects structural variants missed by short-read sequencing.

The paper generates zebrafish models of candidate human epilepsy genes and identifies five genes associated with seizure-like behavior and hyperexcitability.

The paper identifies SMC3 loss-of-function variants associated with variable growth and developmental features, including some unexpected phenotypes like bone marrow failure and leukemia.

The paper investigates the role of the SAGA core module during Drosophila oogenesis and finds it is genetically essential despite the enzymatic modules being dispensable.

The paper identifies a species-specific retrotransposon promoter that generates a conserved Cdk2ap1 isoform essential for preimplantation development across mammals.

The paper improves TE expression quantification in scRNA-seq by developing a pipeline that uses bulk RNA-seq references and captures TE-containing ncRNA transcripts with tissue specificity.