Author

Hazel Davidson‐Smith

Institute of Genetics and Cancer

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genetics· 2 Genomics· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 4 Organism:human· 4 Approach:statistical model· 4 Assay:DNA methylation· 3 Research Focus:gene regulatory network inference· 3 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Assay:ChIP-seq· 1

Frequent Co-Authors

Duncan SprouliD· 3 shared Francesca Taglini· 3 shared Ioannis KafetzopoulosiD· 3 shared Cristina Rubio-Ramon· 2 shared Hannah FinaniD· 2 shared Jimi C. WillsiD· 2 shared Kamila Irena MusialikiD· 2 shared Laura C. MurphyiD· 2 shared

Activity by Year

2018-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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3 shared papersGenetics

Duncan SproulORCID

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Author profile →

4 papers

Recent·Most cited

DNMT1 loss leads to hypermethylation of a subset of late replicating domains by DNMT3A

Ioannis Kafetzopoulos, Francesca Taglini, Moira Pasquier, Hazel Davidson‐Smith, Christine J. Rodger, Lucia Puchades Gimeno, Andrew A. Malcolm, Duncan Sproul

This study shows that DNMT1 loss causes hypomethylation in late replicating domains but also leads to hypermethylation in some domains due to DNMT3A activity, altering chromatin states.

PLoS Genetics · Apr 2, 2026Peer-reviewedGenomics

DNMT3B PWWP mutations cause hypermethylation of heterochromatin

Francesca Taglini, Ioannis Kafetzopoulos, Willow Rolls, Kamila Irena Musialik, Heng Yang Lee, Yujie Zhang, Mattia Marenda, Lyndsay Kerr, Hannah Finan, Cristina Rubio-Ramon, Philippe Emmanuel Gautier, Hannah Wapenaar, Dhananjay Kumar, Hazel Davidson‐Smith, Jimi C. Wills, , Duncan Sproul

This study shows that DNMT3B PWWP mutations cause hypermethylation of heterochromatin marked by H3K9me3, disrupting DNA methylation homeostasis and contributing to ICF syndrome, cancer, and aging.

EMBO Reports · Jan 30, 2024Peer-reviewedGenetics

De novo DNA methyltransferase activity in colorectal cancer is directed towards H3K36me3 marked CpG islands

Roza H. Ali Masalmeh, Francesca Taglini, Cristina Rubio-Ramon, Kamila Irena Musialik, Jonathan Higham, Hazel Davidson‐Smith, Ioannis Kafetzopoulos, Kamila P. Pawlicka, Hannah Finan, Richard C. Clark, Jimi C. Wills, Andrew J. Finch, Lee Murphy, Duncan Sproul

The paper shows de novo DNA methyltransferases in colorectal cancer target H3K36me3-marked CpG islands, similar to normal tissues, rather than sequence-specific CpG islands.

Nature Communications · Jan 29, 2021Peer-reviewedGenetics

DISC1 regulates N-Methyl-D-Aspartate receptor dynamics: Abnormalities induced by a Disc1 mutation modelling a translocation linked to major mental illness

Elise L.V. Malavasi, Kyriakos D. Economides, Ellen Grünewald, Paraskevi Makedonopoulou, Philippe Emmanuel Gautier, Shaun Mackie, Laura C. Murphy, Hannah Murdoch, Darragh Crummie, Fumiaki Ogawa, Daniel L. McCartney, Shane T. O’Sullivan, Karen Burr, Helen Scott Torrance, Jonathan Phillips, , J. Kirsty Millar

This study shows that a DISC1 mutation linked to mental illness disrupts NMDAR dynamics and synaptic function in neurons, affecting excitatory synapses and vesicle dynamics.

Translational Psychiatry · Sep 6, 2018Peer-reviewedNeuroscience