Lyndsay Kerr

DNMT3B PWWP mutations cause hypermethylation of heterochromatin

This study shows that DNMT3B PWWP mutations cause hypermethylation of heterochromatin marked by H3K9me3, disrupting DNA methylation homeostasis and contributing to ICF syndrome, cancer, and aging.

Genome-wide single-molecule analysis of long-read DNA methylation reveals heterogeneous patterns at heterochromatin

The paper uses single-molecule long-read DNA methylation data to show that bulk-level metrics underestimate heterogeneity in the methylome, particularly in heterochromatic regions.

Local CpG density affects the trajectory of age-associated epigenetic changes

The paper shows that local CpG density influences age-related DNA methylation changes in humans by analyzing longitudinal methylation data and SNP data from 600 individuals.

Cluster mean-field theory accurately predicts statistical properties of large-scale DNA methylation patterns

This paper shows that a cluster mean-field model accurately predicts statistical properties of large-scale DNA methylation patterns and can infer model parameters from data.