Yu Erica Lee

This study tracks the development of human autoantibodies against interferons over time, revealing their maturation, specificity, and synergistic effects in blocking IFN signaling.

This study shows that structure-guided vaccination can elicit broadly neutralizing antibodies targeting the HIV-1 silent face, expanding vaccine strategies.

This study identifies and characterizes human monoclonal antibodies targeting conserved coronavirus spike S2 epitopes, revealing distinct antiviral functions and Fc-dependent protective mechanisms.

This study identifies hr2.016, a potent and broad SARS-CoV-2 neutralizing antibody, and shows its neutralization depends on kinetic stability and avidity.

This study identifies two antibodies that recognize conserved SARS-CoV-2 RBD epitopes, revealing structural mechanisms for broad neutralization and escape pathways.

The paper designs bispecific antibodies that retain neutralization activity against multiple SARS-CoV-2 variants, including Omicron subvariants.

The paper identifies an antibody response against Staphylococcus epidermidis and shows how it can be engineered for therapeutic vaccination.

The paper classifies neutralizing antibodies against SARS-CoV-2 spike RBD based on structure, identifying binding modes and implications for vaccine and therapeutic strategies.