Michael R. Eso

Structure-guided vaccination elicits broadly neutralizing antibodies targeting the HIV-1 silent face

This study shows that structure-guided vaccination can elicit broadly neutralizing antibodies targeting the HIV-1 silent face, expanding vaccine strategies.

Structural basis of diverse antibody recognition of conserved coronavirus spike S2 epitopes that contribute to protective immunity

This study identifies and characterizes human monoclonal antibodies targeting conserved coronavirus spike S2 epitopes, revealing distinct antiviral functions and Fc-dependent protective mechanisms.

Dissociation kinetics and avidity gate SARS-CoV-2 neutralization by HR2 stem helix antibodies

This study identifies hr2.016, a potent and broad SARS-CoV-2 neutralizing antibody, and shows its neutralization depends on kinetic stability and avidity.

Structural and mutational analyses define distinct molecular routes to broad SARS-CoV-2 receptor-binding domain recognition

This study identifies two antibodies that recognize conserved SARS-CoV-2 RBD epitopes, revealing structural mechanisms for broad neutralization and escape pathways.

Structural Definition of Neutralizing Epitopes within and around the HKU1 Receptor-binding Site Reveals Cell Context-Dependent Neutralization

This study identifies mAbs targeting HCoV-HKU1 spike protein and shows that receptor-binding site recognition alone does not predict neutralization in primary cells.

Bispecific antibodies with broad neutralization potency against SARS-CoV-2 variants of concern

The paper designs bispecific antibodies that retain neutralization activity against multiple SARS-CoV-2 variants, including Omicron subvariants.