Janice D. Pata

This study determines the structural basis of multitasking by the apicoplast DNA polymerase from Plasmodium falciparum using cryoEM, revealing how it balances replicative and lesion bypass synthesis.

The paper shows mosaic-8b nanoparticles induce broader cross-reactive antibodies than homotypic ones, even in pre-vaccinated animals, suggesting potential for improved vaccine design against emerging sarbecoviruses.

This study identifies AbmR as a dual-function transcription factor and ribonucleoprotein in Mtb that binds DNA and RNA with distinct determinants, affecting gene regulation and RNA stability.