Yi Li

The paper identifies a druggable groove on DeltaFOSB that allows small molecules to modulate its DNA binding and release, with one compound reducing genomic occupancy by 60% in vivo.

This paper demonstrates the creation of YL0441, a highly effective inhibitor of DeltaFOSB that reduces genomic DNA binding sites by ~94% in APP mice.

This study develops a functional screening method to identify TCR-like antibodies targeting tumor neoantigens, demonstrating their anti-tumor efficacy in vitro and in vivo.

This study shows BRD4 regulates alternative splicing of immune-related genes in airway epithelial cells during viral infection, affecting innate inflammation and protein processing.