Jia Zhou

Discovery of Small Molecules and a Druggable Groove That Regulate DNA Binding and Release of the AP1 Transcription Factor DeltaFOSB

The paper identifies a druggable groove on DeltaFOSB that allows small molecules to modulate its DNA binding and release, with one compound reducing genomic occupancy by 60% in vivo.

Efficient in vivo pharmacological inhibition of deltaFOSB, an AP1 transcription factor, in brain

This paper demonstrates the creation of YL0441, a highly effective inhibitor of DeltaFOSB that reduces genomic DNA binding sites by ~94% in APP mice.

YX0798 Is a Highly Potent, Selective, and Orally Effective CDK9 Inhibitor for Treating Aggressive Lymphoma

This paper identifies YX0798 as a potent, selective, and orally effective CDK9 inhibitor that overcomes therapeutic resistance in lymphoma by inducing transcription reprogramming and cell death.

Bromodomain-containing Protein 4 Regulates Innate Inflammation in Airway Epithelial Cells via Modulation of Alternative Splicing

This study shows BRD4 regulates alternative splicing of immune-related genes in airway epithelial cells during viral infection, affecting innate inflammation and protein processing.

Inhibition of BET family proteins suppresses African swine fever virus infection

This study identifies BET/BRD4 inhibitors that suppress ASFV infection in pig macrophages by targeting viral replication and transcription.