MicrobiologybioRxivPreprint
Deletion of a KSF Motif Attenuates NSP1 Host Cell Translation Shutoff and Impairs SARS-CoV-2 Virulence
Chengjin Ye, Shahrzad Ezzatpour, Brian Imbiakha…·Hector C. Aguilar
This study shows that a deletion in the NSP1 protein of SARS-CoV-2 variants reduces virulence by impairing host translation shutoff, suggesting NSP1 as a target for antiviral strategies.
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