Brian Imbiakha

This paper develops a bireporter recombinant SARS-CoV-2 Omicron BA.5 strain for tracking viral infections and testing antivirals and neutralizing antibodies in vitro and in vivo.

This study shows that a deletion in the NSP1 protein of SARS-CoV-2 variants reduces virulence by impairing host translation shutoff, suggesting NSP1 as a target for antiviral strategies.

This study identifies the L260F mutation in NSP6 as enhancing RNA replication and pathogenesis in recent SARS-CoV-2 variants, independent of Spike function.

This study shows that olcegepant reduces weight loss and IL-6 release in older mice infected with SARS-CoV-2, suggesting potential neuroprotective effects against coronavirus-induced inflammation.