Author

David W. Buchholz

Cornell University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Organism:human· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

Brian ImbiakhaiD· 3 shared Hector C. AguilariD· 3 shared Annette ChoiiD· 2 shared Chengjin YeiD· 2 shared Gary R. WhittakeriD· 2 shared Julie SahleriD· 2 shared Luis Martínez‐SobridoiD· 2 shared Mason C. JageriD· 2 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersMicrobiology

Brian ImbiakhaORCID

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Author profile →

3 papers

Recent·Most cited

Deletion of a KSF Motif Attenuates NSP1 Host Cell Translation Shutoff and Impairs SARS-CoV-2 Virulence

Chengjin Ye, Shahrzad Ezzatpour, Brian Imbiakha, Nathaniel D. Jackson, Tolga Çağatay, Anastasija Čupić, Lisa Miorin, Annette Choi, David W. Buchholz, Jordan Carter, Julie Sahler, Ximena A. Olarte‐Castillo, Mason C. Jager, Gary R. Whittaker, Avery August, , Hector C. Aguilar

This study shows that a deletion in the NSP1 protein of SARS-CoV-2 variants reduces virulence by impairing host translation shutoff, suggesting NSP1 as a target for antiviral strategies.

bioRxiv · Apr 16, 2025 · PreprintMicrobiology

Enhanced RNA replication and pathogenesis in recent SARS-CoV-2 variants harboring the L260F mutation in NSP6

Taha Y. Taha, Shahrzad Ezzatpour, Jennifer M. Hayashi, Chengjin Ye, Francisco José Zapatero Belinchón, Julia Rosecrans, Gabriella R. Kimmerly, Irene P. Chen, Keith Walcott, Anna Kurianowicz, Danielle M. Jorgens, Natalie R. Chaplin, Annette Choi, David W. Buchholz, Julie Sahler, , Mélanie Ott

This study identifies the L260F mutation in NSP6 as enhancing RNA replication and pathogenesis in recent SARS-CoV-2 variants, independent of Spike function.

PLoS Pathogens · Mar 31, 2025Peer-reviewedMicrobiology

Migraine inhibitor olcegepant reduces weight loss and IL-6 release in SARS-CoV-2 infected older mice with neurological signs

Shafaqat M. Rahman, David W. Buchholz, Brian Imbiakha, Mason C. Jager, Justin Leach, Raven M. Osborn, Ann O. Birmingham, Stephen Dewhurst, Hector C. Aguilar, Anne E. Luebke

This study shows that olcegepant reduces weight loss and IL-6 release in older mice infected with SARS-CoV-2, suggesting potential neuroprotective effects against coronavirus-induced inflammation.

Journal of Virology · May 30, 2024Peer-reviewedNeuroscience