Hector C. Aguilar

This study compares the pathogenicity and transmissibility of bovine- and human-derived H5N1 viruses in mouse and hamster models, finding high pathogenicity but limited transmissibility.

This paper develops a bireporter recombinant SARS-CoV-2 Omicron BA.5 strain for tracking viral infections and testing antivirals and neutralizing antibodies in vitro and in vivo.

This study shows the SARS-CoV-2 nucleocapsid protein drives hyperinflammation and vascular leakage in macrophages via Toll-like receptor signaling, contributing to severe COVID-19 complications.

This study uses cryo-electron tomography to analyze the structural organization of Nipah virus proteins in virus-like particles, revealing novel interactions and structural features.

This paper develops a cell-free method to produce Nipah virus membrane proteins in liposomes for vaccine design, showing improved protein incorporation and enhanced immune responses in mice.

This study shows that a deletion in the NSP1 protein of SARS-CoV-2 variants reduces virulence by impairing host translation shutoff, suggesting NSP1 as a target for antiviral strategies.

This study identifies the L260F mutation in NSP6 as enhancing RNA replication and pathogenesis in recent SARS-CoV-2 variants, independent of Spike function.

This study shows that olcegepant reduces weight loss and IL-6 release in older mice infected with SARS-CoV-2, suggesting potential neuroprotective effects against coronavirus-induced inflammation.

The paper uses CRISPR screens to identify mucins as key host factors that restrict SARS-CoV-2 infection in human lung cells.