Shafaqat M. Rahman

Comparing the Impact of Systemic Pituitary Adenylate-Cyclase-Activating Polypeptide (PACAP) and Calcitonin Gene-Related Peptide (CGRP) on Motion-induced Nausea and Balance Behaviors In Mice

This study examines the effects of PACAP-38 and CGRP on motion-induced nausea and balance in mice, finding PACAP-38 disrupts thermoregulation and balance in females but not rotarod performance.

Systemic Calcitonin Gene-Related Peptide (CGRP) modifies auditory and vestibular end organ electrical potentials, and increases sensory hypersensitivities

This study shows that systemic CGRP modulates inner ear potentials and induces migraine-like behaviors in mice, suggesting a direct role for CGRP in auditory and vestibular hypersensitivities.

Human RAMP1 overexpressing mice are resistant to migraine therapies for motion sensitivity

This study shows that overexpressing human RAMP1 in mice increases CGRP signaling and makes them resistant to migraine treatments like olcegepant and rizatriptan.

Loss of Calcitonin gene-related Related Receptor component protein (RCP) in nervous system can bias gepant antagonism

The paper investigates the effect of RCP loss in a mouse model on CGRP receptor antagonism, finding that olcegepant fails to antagonize CGRP effects in RCP-deficient mice.

Migraine inhibitor olcegepant reduces weight loss and IL-6 release in SARS-CoV-2 infected older mice with neurological signs

This study shows that olcegepant reduces weight loss and IL-6 release in older mice infected with SARS-CoV-2, suggesting potential neuroprotective effects against coronavirus-induced inflammation.

Calcitonin Gene-Related Peptide (CGRP) Receptor Antagonism Reduces Motion Sickness Indicators in Mouse Migraine Models

This study shows that CGRP receptor antagonists reduce motion-induced nausea in mouse migraine models, while triptans are ineffective.

Both systemic Calcitonin Gene Related Peptide (CGRP) and a vestibular challenge promote anxiety-related behaviors and dynamic imbalance in mice

This study shows that systemic CGRP and vestibular stimulation increase anxiety and imbalance in mice, with stronger effects in females and on specific balance challenges.

Age-Related Balance Problems in Mice Are Sharpened by the Loss of Calcitonin Gene-Related Peptide (CGRP) and a Vestibular Challenge

This study shows that loss of CGRP in aging mice leads to impaired balance, with worse performance on rotarod and increased postural instability after vestibular challenges.