Author

Pavla Vaňková

Czech Academy of Sciences, Institute of BiotechnologyORCID 0000-0001-8722-2586Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 2 Biophysics· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 3 Research Focus:protein folding & dynamics· 2 Assay:structural biology· 2 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:drug response / drug discovery· 1 Approach:mechanistic / dynamical model· 1 Assay:protein structure· 1

Frequent Co-Authors

Petr ManiD· 4 shared Dmitry S. LoginoviD· 3 shared Angel Luis PeyiD· 2 shared Juan Luis Pacheco‐GarcíaiD· 2 shared Albane le MaireiD· 1 shared Alberto GiacomelloiD· 1 shared Amin SagariD· 1 shared Atanasio Gómez‐MulasiD· 1 shared

Activity by Year

2025-2025 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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4 shared papersBiochemistry

Petr ManORCID

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4 papers

Recent·Most cited

BiochemistryNature CommunicationsPeer-reviewedNov 28, 2025

Structural mechanisms of allosteric regulation in the human cis-prenyltransferase complex

Moshe Giladi, Shiri Kredi, Carlo Guardiani…·Yoni Haitin

This study identifies the structural basis of allosteric regulation in the human cis-prenyltransferase complex using a combination of experimental and computational methods.

3 citations

humanstructural biology

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BiochemistryNucleic Acids ResearchPeer-reviewedSep 23, 2025

New structural insights into the control of the retinoic acid receptors RAR/RXR by DNA, ligands and transcriptional coregulators

Izabella Tambones, Amin Sagar, Pavla Vaňková…·Albane le Maire

This study reveals how DNA sequence and ligand binding influence the structural dynamics of RAR/RXR-coregulator complexes through integrative structural analysis.

10 citations

structural biologyexperimental assay

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BiophysicsbioRxivPreprintApr 12, 2025

Nanobodies as therapies for loss-of-function misfolding diseases.

Atanasio Gómez‐Mulas, Mirco Dindo, Juan Luis Pacheco‐García…·Angel Luis Pey

This study develops and characterizes six nanobodies as potential therapeutics for PH1 by targeting misfolded AGT variants, showing high affinity and functional enhancement in cellular models.

DOI 10.1101/2025.04.12.648492

humanprotein structure

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BiophysicsbioRxivPreprintFeb 2, 2025

Active site tyrosine residues in human NQO1 homodimer are critical for non-synchronous enzyme catalysis at the two active sites.

Maribel Rivero, Juan Luis Pacheco‐García, Pavla Vaňková…·Angel Luis Pey

This study investigates the role of Tyr126 and Tyr128 in human NQO1 catalysis, showing their critical impact on enzyme activity and non-synchronous catalysis.

DOI 10.1101/2025.02.02.636097

humanexperimental assay

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