Xuhang Li

The paper introduces Worm Perturb-Seq (WPS) to perform high-resolution RNA-seq on perturbed C. elegans, identifying gene regulatory networks and showing pairwise modularity in nuclear hormone receptor regulation.

The paper demonstrates how enzyme levels influence metabolic flux through three paradigms and introduces an algorithm to predict flux changes from enzyme expression in yeast and humans.

The paper manually annotates and visualizes metabolic pathways in C. elegans, providing pathway maps for metabolic enrichment analysis of transcriptomic data.

The paper identifies two mechanisms by which vitamin B12 regulates the methionine/S-adenosylmethionine cycle in C. elegans, involving transcriptional adjustments via nuclear hormone receptors.