Hefei Zhang

Worm Perturb-Seq: massively parallel whole-animal RNAi and RNA-seq

The paper introduces Worm Perturb-Seq (WPS) to perform high-resolution RNA-seq on perturbed C. elegans, identifying gene regulatory networks and showing pairwise modularity in nuclear hormone receptor regulation.

Kiaa1024L/Minar2 is essential for hearing by regulating cholesterol distribution in hair bundles

This study identifies Kiaa1024L/Minar2 as essential for hearing by regulating cholesterol distribution in hair bundles, showing that its loss causes deafness in zebrafish.

Bacterial diet modulates tamoxifen-induced death via host fatty acid metabolism

The paper shows that different bacteria modulate tamoxifen toxicity in C. elegans through fatty acid metabolism, with varying death mechanisms and FA profiles.

WormPaths: Caenorhabditis elegans metabolic pathway annotation and visualization

The paper manually annotates and visualizes metabolic pathways in C. elegans, providing pathway maps for metabolic enrichment analysis of transcriptomic data.

C. elegans methionine/S-adenosylmethionine cycle activity is sensed and adjusted by a nuclear hormone receptor

The paper identifies two mechanisms by which vitamin B12 regulates the methionine/S-adenosylmethionine cycle in C. elegans, involving transcriptional adjustments via nuclear hormone receptors.