Author

Melissa D. Walker

University of Massachusetts Chan Medical School

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Systems Biology· 3 Genetics· 1

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Organism:C. elegans· 3 Approach:experimental assay· 3 Research Focus:database / resource· 1 Assay:DNA methylation· 1 Organism:E. coli· 1 Research Focus:gene regulatory network inference· 1 Approach:statistical model· 1

Frequent Co-Authors

Albertha J.M. WalhoutiD· 4 shared Gabrielle E. GieseiD· 3 shared Hefei ZhangiD· 3 shared Olga PonomarovaiD· 3 shared Amy D. HoldorfiD· 2 shared Aurian P. García-GonzáleziD· 2 shared Cédric DiotiD· 2 shared Huimin NaiD· 2 shared

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2019-2022 · peak 1/yr

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10 top collaborators · 45 mutual co-author links

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4 shared papersSystems Biology

Albertha J.M. WalhoutORCID

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4 papers

Recent·Most cited

Bacterial diet modulates tamoxifen-induced death via host fatty acid metabolism

Cédric Diot, Aurian P. García-González, Andre F.C. Vieira, Melissa D. Walker, Megan E. Honeywell, Hailey Doyle, Olga Ponomarova, Yomari Rivera, Huimin Na, Hefei Zhang, Michael J. Lee, Carissa Perez Olsen, Albertha J.M. Walhout

The paper shows that different bacteria modulate tamoxifen toxicity in C. elegans through fatty acid metabolism, with varying death mechanisms and FA profiles.

Nature Communications · Sep 23, 2022Peer-reviewedSystems Biology

WormPaths: Caenorhabditis elegans metabolic pathway annotation and visualization

Melissa D. Walker, Gabrielle E. Giese, Amy D. Holdorf, Sushila Bhattacharya, Cédric Diot, Aurian P. García-González, Brent B. Horowitz, Yong‐Uk Lee, Thomas B. Leland, Xuhang Li, Zeynep Mirza, Huimin Na, Shivani Nanda, Olga Ponomarova, Hefei Zhang, , Albertha J.M. Walhout

The paper manually annotates and visualizes metabolic pathways in C. elegans, providing pathway maps for metabolic enrichment analysis of transcriptomic data.

Genetics · Jun 12, 2021Peer-reviewedGenetics

C. elegans methionine/S-adenosylmethionine cycle activity is sensed and adjusted by a nuclear hormone receptor

Gabrielle E. Giese, Melissa D. Walker, Olga Ponomarova, Hefei Zhang, Xuhang Li, Gregory Minevich, Albertha J.M. Walhout

The paper identifies two mechanisms by which vitamin B12 regulates the methionine/S-adenosylmethionine cycle in C. elegans, involving transcriptional adjustments via nuclear hormone receptors.

eLife · Oct 5, 2020Peer-reviewedSystems Biology

A Persistence Detector for Metabolic Network Rewiring in an Animal

Jote Bulcha, Gabrielle E. Giese, Md Zulfikar Ali, Yong‐Uk Lee, Melissa D. Walker, Amy D. Holdorf, Lutfu Safak Yilmaz, Robert C. Brewster, Albertha J.M. Walhout

The paper identifies a persistence detector in an animal that redirects propionate breakdown to a shunt pathway when flux through the canonical pathway is perturbed.

Cell Reports · Jan 1, 2019Peer-reviewedSystems Biology