Caleb Weinreb

Keypoint-MoSeq fits a generative model that tells tracking jitter apart from real movement, cutting pose time series into unsupervised sub-second behavioural syllables in mice.

The paper uses single-cell RNA sequencing to study how transcriptional changes during neurogenesis lead to the sequential generation of distinct septal neuron types.

The paper identifies non-neuronal cell types in the olfactory system expressing SARS-CoV-2 entry genes, suggesting indirect mechanisms for COVID-19-associated anosmia.

This study uses DNA barcodes to trace single-cell transcriptomes during differentiation, identifying fate biases and developmental hierarchies in hematopoiesis.

This paper identifies fundamental limits on inferring gene expression dynamics from single-cell snapshots and introduces an algorithmic approach to constrain dynamic solutions.

The paper uses single-cell transcriptomics and fate potential assays to map the erythroid differentiation trajectory from multipotent hematopoietic stem cells in mice, revealing novel regulators and transcriptional programs.

SPRING visualizes high-dimensional single-cell expression data using force-directed layouts, revealing more detailed biological relationships and greater reproducibility than existing methods.