Author

Ruwanthi N. Gunawardane

Allen Institute for Cell ScienceORCID 0000-0002-2698-5245Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 3 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Research Focus:differential expression· 3 Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:clustering· 1

Frequent Co-Authors

Brock RobertsiD· 4 shared Jacqueline E. Smith· 3 shared Alison Schroer Vander RoestiD· 2 shared Beth L. PruittiD· 2 shared Daniel BernsteiniD· 2 shared David L. MackiD· 2 shared Erik A. EhlersiD· 2 shared Gaea Turman· 2 shared

Activity by Year

2023-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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4 shared papersCell Biology

Brock RobertsORCID

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4 papers

Recent·Most cited

Cell BiologyNature MethodsPeer-reviewedJun 15, 2026

A human induced pluripotent stem (hiPS) cell model for the holistic study of epithelial to mesenchymal transitions (EMTs)

Caroline Hookway, Antoine Borensztejn, Leigh K. Harris…·Susanne M. Rafelski

The paper presents a hiPS cell model to study EMTs by comparing 2D and 3D cultures, measuring changes in cell function, markers, organization, and environment.

3 citationstop 4%

humanimaging

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Cell BiologybioRxivPreprintJun 3, 2024

YAP dysregulation triggers hypertrophy by CCN2 secretion and TGFβ uptake in human pluripotent stem cell-derived cardiomyocytes

Orlando Chirikian, Mohamed A. Faynus, Markus W. Merk…·Beth L. Pruitt

This study shows that YAP overactivation in HCM mutant cardiomyocytes drives hypertrophy via CCN2 secretion and TGFβ uptake.

1 citation

humanbulk RNA-seq

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Cell BiologybioRxivPreprintMay 24, 2024

Enhanced endogenous gene tagging in human induced pluripotent stem cells via AAV6-mediated donor delivery

Erik A. Ehlers, Kyle N. Klein, Margaret A. Fuqua…·Brock Roberts

This paper develops a method to efficiently insert fluorescent tags into genes not expressed in hiPSCs using AAV6 delivery, optimized CRISPR conditions, and ddPCR/ICE to minimize INDELs and isolate tagged clones.

3 citations

humanCRISPR screen

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Molecular BiologybioRxivPreprintJun 8, 2023

Multi-scale models reveal hypertrophic cardiomyopathy MYH7 G256E mutation drives hypercontractility and elevated mitochondrial respiration

Soah Lee, Alison Schroer Vander Roest, Cheavar A. Blair…·Daniel Bernstein

This study investigates the effects of the MYH7 G256E mutation on myosin function across multiple scales, finding increased hypercontractility and mitochondrial respiration.

2 citations

humanscRNA-seq

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