Author

Jacqueline E. Smith

Allen Institute for Cell Science

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 3 Organism:human· 3 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Assay:CRISPR screen· 1 Approach:deep learning· 1

Frequent Co-Authors

Brock RobertsiD· 3 shared Ruwanthi N. GunawardaneiD· 3 shared Alison Schroer Vander RoestiD· 2 shared Beth L. PruittiD· 2 shared Daniel BernsteiniD· 2 shared David L. MackiD· 2 shared Orlando ChirikianiD· 2 shared Alex ChialastriiD· 1 shared

Activity by Year

2023-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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3 shared papersCell Biology

Brock RobertsORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

YAP dysregulation triggers hypertrophy by CCN2 secretion and TGFβ uptake in human pluripotent stem cell-derived cardiomyocytes

Orlando Chirikian, Mohamed A. Faynus, Markus W. Merk, Zachary Singh, Christopher Muray, J. Pham, Alex Chialastri, Alison Schroer Vander Roest, Alex J. Goldstein, Trevor Pyle, Kerry V. Lane, Brock Roberts, Jacqueline E. Smith, Ruwanthi N. Gunawardane, Nathan J. Sniadecki, , Beth L. Pruitt

This study shows that YAP overactivation in HCM mutant cardiomyocytes drives hypertrophy via CCN2 secretion and TGFβ uptake.

bioRxiv · Jun 3, 2024 · PreprintCell Biology

Enhanced endogenous gene tagging in human induced pluripotent stem cells via AAV6-mediated donor delivery

Erik A. Ehlers, Kyle N. Klein, Margaret A. Fuqua, Julia R. Torvi, Javier Chávez, Lauren M. Kuo, Jacob McCarley, Jacqueline E. Smith, Gaea Turman, Danielle Yi, Ruwanthi N. Gunawardane, Brock Roberts

This paper develops a method to efficiently insert fluorescent tags into genes not expressed in hiPSCs using AAV6 delivery, optimized CRISPR conditions, and ddPCR/ICE to minimize INDELs and isolate tagged clones.

bioRxiv · May 24, 2024 · PreprintCell Biology

Multi-scale models reveal hypertrophic cardiomyopathy MYH7 G256E mutation drives hypercontractility and elevated mitochondrial respiration

Soah Lee, Alison Schroer Vander Roest, Cheavar A. Blair, Kerry Y. Kao, Samantha B. Bremner, Matthew Carter Childers, Divya Pathak, Paul Heinrich, Daniel C. Lee, Orlando Chirikian, Saffie E. Mohran, Brock Roberts, Jacqueline E. Smith, James W.S. Jahng, David T. Paik, , Daniel Bernstein

This study investigates the effects of the MYH7 G256E mutation on myosin function across multiple scales, finding increased hypercontractility and mitochondrial respiration.

bioRxiv · Jun 8, 2023 · PreprintMolecular Biology