Benoı̂t Delatour

Experimental and natural peripheral HSV-1 infection: Neurotropism and impact on Alzheimer's disease-related molecular markers

This study investigates the role of HSV-1 infection in Alzheimer's disease by analyzing its impact on Aβ and Tau pathologies in animal models, postmortem brain samples, and AD patients.

Automated segmentation by deep learning of neuritic plaques and neurofibrillary tangles in brain sections of Alzheimer's Disease Patients

This paper develops a deep learning workflow to automate the segmentation of neuritic plaques and neurofibrillary tangles in Alzheimer's brain sections, achieving high accuracy and consistency across diverse tissue samples.

Mapping Alzheimer Disease Molecular Pathologies in Large-Scale Connectomics Data: A Publicly Accessible Correlative Microscopy Resource

The paper presents a vCLEM protocol to map Aβ and pTau in AD mouse hippocampus connectomics data, revealing new molecular and structural alterations.

Huntingtin-KIF1A-mediated axonal transport of synaptic vesicle precursors influences synaptic transmission and motor skill learning in mice

This study shows that HTT phosphorylation recruits KIF1A to enhance axonal transport of synaptic vesicle precursors, increasing glutamate release and impairing motor learning in mice.

Endogenous pathology in tauopathy mice progresses via brain networks

The paper uses whole-brain imaging to show that tau pathology in mice propagates retrogradely through brain networks.

Presynaptic APP levels and synaptic homeostasis are regulated by Akt phosphorylation of Huntingtin

This study shows that Akt phosphorylation of Huntingtin regulates axonal transport of APP and presynaptic levels, affecting synaptic homeostasis and learning.

Huntingtin phosphorylation governs BDNF homeostasis and improves the phenotype of Mecp2 knockout mice

This study shows that increasing HTT phosphorylation at Ser421 improves BDNF transport, striatal BDNF availability, and the phenotype of Mecp2 knockout mice.