Meredith S. Gregory-Ksander

The paper identifies resilience factors in aged mice using a genome-scale ORF screen, finding NKX2-5 variants that restore vision and reduce frailty.

This study improves human donor retinal ganglion cell survival by modulating host microglia using annexin V and soluble Fas ligand, increasing survival by 2.5-fold.

OSK factors rejuvenate aged RPE cells by activating a Tet2-independent oxidative resilience pathway through GSTA4, restoring vision and reversing age-related degeneration.

This study creates a murine model of complete limbal stem cell deficiency with residual stem cells to investigate their function.

This study shows retinal microglia are critical antigen-presenting cells in uveitis, essential for all phases of disease, while CD11c+ DCs are not required for all phases.

The paper shows that DNA double-strand breaks induce epigenomic changes that accelerate the aging clock in mammals.

This paper demonstrates that epigenetic reprogramming using OSK genes can reverse age-related and injury-induced vision loss in mice by resetting DNA methylation patterns and promoting axon regeneration.