Sarah Keegan

This study defines the single-cell landscape of Class II lupus nephritis and identifies fibroblast transcriptional programs and chronicity index as potential predictors of kidney outcomes.

This study shows HSV-1 protein ICP4 increases nuclear fluidity to enable condensate formation, supporting viral replication.

This study examines how HSV-1 ICP4 expression in uninfected cells alters host gene expression through RNA-Seq, identifying differentially expressed genes and validating findings against infected cell data.

This paper introduces a method to temporally control Cas9 DNA targeting by coupling it with transcription through engineered RNA binding, enabling selective gene editing in yeast and human cells.

This study shows D-type cyclins inhibit mismatch repair (MMR) in G1 phase by shielding p21, while their degradation in S phase enables proper MMR function, maintaining genome stability.

This paper develops a machine learning approach to classify 53BP1 foci in 2D images, achieving high performance with standard classifiers and a diverse parameter space.

This study shows that DNA replication initiation and termination in human cells are coupled with transcription, with initiation near transcription start sites and termination at polyadenylation sites.

The paper introduces a method to quantify molecular interactions using stochastic modeling and super-resolution microscopy, validated with simulated and experimental data.

The paper develops a collection of 1406 validated monoclonal antibodies against human transcription factors and identifies factors contributing to their successful generation.