Joshua C. Vaughan

A Human Precision Cut Kidney Slice Platform for Studying Glomerular Biology and Therapeutic Responses

This study uses human precision cut kidney slices to analyze gene expression responses to culture conditions and IFNγ stimulation, showing reproducible APOL1 expression changes.

High-throughput, organ-scale 3D tubule tracking using TubuleMAP

The paper introduces TubuleMAP, a semi-automated 3D tubule tracking pipeline for analyzing tubular networks, achieving high throughput and accuracy in reconstructing kidney and testis tubules.

Nanoscale Optical Imaging, Reconstruction, and Spatial Analysis of Whole Mouse Glomeruli

The paper develops a pipeline for high-resolution imaging and analysis of whole mouse glomeruli, revealing novel aging and disease-related phenotypes.

Multiplexed single-cell profiling of chromatin states at genomic loci by expansion microscopy

The paper introduces SCEPTRE, a method combining expansion microscopy with histone modification analysis to study chromatin states in single cells at high resolution.

A conserved morphogenetic mechanism for epidermal ensheathment of nociceptive sensory neurites

This study identifies a conserved morphogenetic mechanism by which epidermal cells ensheath somatosensory neurites, contributing to nociceptive function in Drosophila and zebrafish.