Jessica A. Engel

This study shows that TGF-β signaling in CD4 T cells regulates the balance between protective and regulatory immunity in visceral leishmaniasis by controlling T cell expansion, differentiation, and effector function.

This study examines CD4+ T cell responses in visceral leishmaniasis using single-cell RNA sequencing, revealing transcriptional heterogeneity and regulatory mechanisms affecting immune function.

Single-cell RNA and BCR sequencing of infected mouse spleens shows class switching overlaps clonal expansion, GC-seeding clones also form plasmablasts, and SHM proceeds at constant rate.

This study shows that myeloid HDAC7 promotes liver inflammation and glucose dysregulation in obesity, using mouse models and human data.

This study investigates the role of NKG7 in CD4+ and CD8+ T cells during malaria, showing protective and cell-intrinsic functions in different infection models and human infections.