TGF-β signalling regulates the balance between protective and regulatory CD4+ T cell responses in visceral leishmaniasis
Jinrui Na, Fabian de Labastida Rivera, Teija C. M. Frame, Luzia Bukali, Jessica A. Engel, Christian R. Engwerda
This study shows that TGF-β signaling in CD4 T cells regulates the balance between protective and regulatory immunity in visceral leishmaniasis by controlling T cell expansion, differentiation, and effector function.
bioRxiv · Aug 7, 2026 · PreprintImmunology