Aliya F Spigelman

This study compares immature stem-cell-derived β-cells to primary β-cells using multi-omic single-cell methods, identifying SREBP1 as a target for improving β-cell maturation.

This study investigates GlyR dysfunction in T2D and high glucose conditions, finding reduced GlyR currents and gene expression, but no splicing changes, and links GlyR activity to gene regulatory networks.

This study identifies TMEM55A as a regulator of α-cell exocytosis and glucagon secretion through PI5P signaling and F-actin remodeling in response to oxidative stress.

This study investigates islet cell dysfunction in type 1 diabetes by integrating electrophysiological, transcriptomic, and machine learning analyses of human islet cells from T1D donors.

The paper examines islet isolation and culture outcomes at the Alberta Diabetes Institute IsletCore, finding islet loss occurs within 24 hours of isolation with no further loss after extended culture.

HumanIslets.com provides an open platform for accessing and analyzing human islet data, enabling research on diabetes through integrated molecular and cellular phenotyping.

A genome-wide CRISPR screen in human pancreatic beta cells identifies 580 genes influencing insulin content, supporting 20 candidate type 2 diabetes effector transcripts.