Author
University of OxfordORCID 0000-0001-8076-1480Unclaimed ORCID profile · follow to get notified of new preprints
5 papers
Recent·Most cited
Yuichi Tsuchiya, Nikita Sergejevs, María Emilia Dueñas…·Pedro Carvalho
The paper identifies how mistargeted mitochondrial proteins are rerouted to the ER and cleared via ERAD, with MARCHF6 playing a central role in maintaining proteostasis during mitochondrial dysfunction.
Adán Pinto-Fernández, Claire Heride, A.P. Turnbull…·Benedikt Mathias Kessler
This study develops refined USP25/28 inhibitors that selectively target c-MYC driven squamous lung cancer cells with reduced off-target effects and toxicity.
Nikolas A. Baya, İlknur Sur‐Erdem, Samvida S. Venkatesh…·Cecilia M. Lindgren
The paper identifies genes associated with obesity and fat distribution using genetic and functional data, then validates their roles through CRISPR knockdown in cell lines.
Marta Perez‐Alcantara, Sam J. Washer, Yixi Chen…·Andrew Roger Bassett
The paper integrates QTL mapping and CRISPR screening in iPSC-derived microglia to identify genetic drivers of neurodegenerative risk by linking variants to phenotypes and gene expression.
Antje K. Rottner, Yingying Ye, Elena Navarro‐Guerrero…·Anna L. Gloyn
A genome-wide CRISPR screen in human pancreatic beta cells identifies 580 genes influencing insulin content, supporting 20 candidate type 2 diabetes effector transcripts.