Kathrin Tomasek

The paper develops a human urothelial organoid model to study urine-urothelium interactions in UTI resilience and UPEC recurrence, finding that high-solute urine weakens tissue and promotes CWD UPEC formation.

The paper introduces SimUrine, a fully defined synthetic urine medium that supports diverse urinary microbiome growth and reveals novel microbial interactions and antimicrobial susceptibility patterns.

This study shows that OM-89 enhances lysosomal activity in bladder epithelial cells, improving antibiotic efficacy against UPEC and reducing bacterial regrowth.

The paper shows that a fixed gene regulatory network can display different phenotypes based on local genetic context, highlighting the role of transcriptional unit order.