Covalent Drug binding in Live Cells Monitored by Mid-IR Quantum Cascade Laser Spectroscopy: Photoactive Yellow Protein as a Model System
Srijit Mukherjee, Steven D.E. Fried, Nathalie Y. Hong, Nahal Bagheri, Jacek Kozuch, Irimpan I. Mathews, Jacob M. Kirsh, Steven G. Boxer
This paper develops a mid-IR quantum cascade laser spectroscopy method to detect drug-target interactions in live cells using photoactive yellow protein as a model system.
bioRxiv · Aug 15, 2025 · PreprintBiophysics