Chi-Lam Poon

This paper reports the first derivation of elephant induced pluripotent stem cells (emiPSCs) using a modified reprogramming protocol that inhibits TP53 expansion genes.

The paper identifies a genetic variant that protects against clonal hematopoiesis by regulating RNA-binding protein MSI2 in hematopoietic stem cells.

MosaicSim simulates mosaic variants in sequencing data to evaluate detection methods, showing that higher coverage improves detection rates without false positives.

The paper introduces tidyomics, an ecosystem bridging Bioconductor and tidy R to streamline omic analysis using data from the Human Cell Atlas.

The paper benchmarks eight tools for identifying and quantifying alternative polyadenylation sites from RNA-seq data using real, synthetic, and 3'-end sequencing data.

ScisorWiz visualizes differential isoform expression in single-cell long-read data, highlighting alternative exons and SNVs across cell types and brain regions.