Artur Scherf

The paper develops an in vitro and in vivo platform for testing malaria transmission-blocking drugs using engineered Plasmodium falciparum gametocytes and humanized mice.

This study identifies taurine as a host metabolite that inhibits malaria parasite cytoadhesion in asymptomatic infections, suggesting its potential as a therapeutic target.

The paper uses Micro-C to map DNA-DNA contacts in Plasmodium falciparum, revealing heterochromatic and euchromatic structures mediated by MORC/ApiAP2 and other factors.

The paper investigates the role of cohesin in regulating stage-specific gene expression in Plasmodium falciparum, showing that SMC3 represses genes until their appropriate time of expression.

The paper characterizes oxidized 5mC forms in Plasmodium falciparum and shows DNMT2 and oxygen levels influence their epigenetic landscape.

The paper identifies a DNA element in the ap2-g gene that modulates heterochromatin spreading in Plasmodium falciparum, revealing a role for RNA-binding proteins in boundary regulation.

This study identifies m6A mRNA methylation dynamics in Plasmodium falciparum during blood-stage development, showing its role in regulating gene expression and mRNA stability.