Author

Rasha T. Kakati

University of North Carolina at Chapel HillORCID 0000-0002-7623-4079Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Assay:proteomics· 1

Frequent Co-Authors

Philip M. SpanheimeriD· 2 shared Adriana S. BeltrániD· 1 shared Ahhyun KimiD· 1 shared Angie L. MordantiD· 1 shared Attila SzénásiiD· 1 shared Austin A. WhitmaniD· 1 shared Charles M. PerouiD· 1 shared Christine ThaiiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersCancer Biology

Philip M. SpanheimerORCID

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2 papers

Recent·Most cited

Kinase Plasticity in Response to Vandetanib Enhances Sensitivity to Tamoxifen in Estrogen Receptor Positive Breast Cancer

Austin A. Whitman, Rasha T. Kakati, Santiago Haase, Christine Thai, Surya Kant Tripathi, Attila Szénási, Elizabeth Brunk, Denis O. Okumu, Michael P. East, Sarahi G. Molina, Adriana S. Beltrán, Jesse R. Raab, LA Carey, Charles M. Perou, Gary L. Johnson, Philip M. Spanheimer

This study shows vandetanib enhances tamoxifen sensitivity in ER+ breast cancer by reprogramming ER gene regulation and kinase networks, identifying adaptive resistance pathways and response signatures.

Molecular Cancer Therapeutics · Jul 28, 2026Peer-reviewedCancer Biology

USP7 inhibition perturbs proteostasis and tumorigenesis in triple negative breast cancer

Ahhyun Kim, Priya Gopalakrishnan, Marina Suarez-Pizarro, Claire C. Chen, Xianxi Wang, Sydney M. McCoy, Nikita Umesh, Angie L. Mordant, Natalie K. Barker, Laura E. Herring, Rasha T. Kakati, Philip M. Spanheimer, Michael J. Emanuele, Claudia A. Benavente

This study shows USP7 inhibition disrupts proteostasis and tumor growth in triple negative breast cancer by stabilizing E3 ubiquitin ligases and affecting DNA repair pathways.

npj Breast Cancer · May 23, 2026Peer-reviewedCancer Biology