Adam D. Gracz

The paper identifies BEC subpopulations and their spatial organization using scRNA-seq and metagenes, revealing subpopulation-specific damage responses in mouse liver.

The paper identifies chromatin features distinguishing injury-responsive from state-stabilizing transcriptional programs in hybrid hepatocytes using multi-omics data.

This paper develops a 3D imaging and analysis pipeline for intrahepatic bile ducts in mouse and human tissues, revealing structural changes in health and disease.

This study shows Tet1 buffers intestinal stem cell differentiation by reducing sensitivity to extrinsic signals, without altering chromatin accessibility.

This study shows that Tritrichomonas muris increases doxorubicin-induced intestinal apoptosis in mice without altering tissue morphology, and reduces intestinal stem cell gene expression post-injury.

This study shows that Lgr5+ intestinal stem cells are necessary for organoid survival after genotoxic injury, despite fISC gene activation occurring at both low and high doses of doxorubicin.

This study shows that Sox9 is essential for the development of small bile ductules during intrahepatic bile duct morphogenesis, with loss of Sox9 leading to impaired branching and BEC maturation.

The paper quantifies chromatin dynamics in intestinal stem cells to identify regulators of differentiation and reveals 5hmC enrichment in absorptive lineage genes.