Author

Carsten Krebs

Pennsylvania State UniversityORCID 0000-0002-3302-7053Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:chromatin & epigenetic regulation· 2 Organism:E. coli· 1 Approach:experimental assay· 1 Research Focus:protein folding & dynamics· 1 Approach:statistical model· 1

Frequent Co-Authors

Amie K. BoaliD· 2 shared Alexey SilakoviD· 1 shared Binju WangiD· 1 shared Eliott S. WengeriD· 1 shared J ZHANGiD· 1 shared Jay V. PendyalaiD· 1 shared Jiahai Zhou· 1 shared Joseph Martin Bollinger Jr.iD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersBiochemistry

Amie K. BoalORCID

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2 papers

Recent·Most cited

Amino Acids in the RSSY Motif of Lipoyl Synthase Control Substrate Binding and Reactivity

Vivian Robert Jeyachandran, Nicholas D. Lanz, Maria‐Eirini Pandelia, Justin M. Rectenwald, Jay V. Pendyala, Ravi K Maurya, Amie K. Boal, Carsten Krebs, Squire J. Booker

This paper investigates the role of amino acids in the RSSY motif of lipoyl synthase, showing that Arg306 and Ser308 are critical for substrate binding and catalytic activity, with specific substitutions affecting product formation and cluster stability.

ACS Bio & Med Chem Au · Aug 5, 2026Peer-reviewedBiochemistry

Metal Coordination Dynamics Governs Selective Epoxidation in Hyoscyamine 6β-Hydroxylase: Integrated Experimental and Computational Insights

J ZHANG, Lian Wu, Siqi Wu, Xiao Liu, Lina Dong, Eliott S. Wenger, Ridao Chen, Carsten Krebs, Alexey Silakov, Amie K. Boal, Joseph Martin Bollinger Jr., Jiahai Zhou, Binju Wang

This paper investigates the catalytic mechanism of hyoscyamine 6β-hydroxylase, revealing that metal coordination dynamics govern selectivity between hydroxylation and epoxidation reactions.

bioRxiv · Jun 3, 2026 · PreprintBiochemistry