Author

Núria Peñuelas

Biomedical Research Networking Center on Neurodegenerative DiseasesORCID 0000-0001-6443-9790Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Organism:rat· 1 Approach:statistical model· 1

Frequent Co-Authors

Alba NicolauiD· 3 shared Annabelle ParentiD· 3 shared Ariadna LagunaiD· 3 shared Marina Lorente PicóniD· 3 shared Marta González-SepúlvedaiD· 3 shared Miquel VilaiD· 3 shared Camille Guillard-SirieixiD· 2 shared Helena XicoyiD· 2 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersNeuroscience

Alba NicolauORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

NeurosciencebioRxivPreprintAug 7, 2026

Age-dependent brain pigmentation drives early neuroinflammatory molecular signatures linked to neurodegeneration

Núria Peñuelas, Helena Xicoy, Marina Lorente Picón…·Miquel Vila

This study identifies age-dependent neuroinflammatory changes in NM-containing neurons linked to neurodegeneration, with GPNMB as a conserved protective factor in Parkinson's disease.

DOI 10.64898/2026.08.03.742448

mousebulk RNA-seq

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NeuroscienceNature CommunicationsPeer-reviewedOct 11, 2024

Modelling human neuronal catecholaminergic pigmentation in rodents recapitulates age-related multisystem neurodegenerative deficits

Ariadna Laguna, Núria Peñuelas, Marta González-Sepúlveda…·Miquel Vila

This paper creates a transgenic mouse model that mimics human neuromelanin accumulation in catecholaminergic neurons, leading to age-related neurodegenerative deficits.

29 citationstop 2%

mouseexperimental assay

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NeuroscienceBrainPeer-reviewedNov 23, 2022

In vivo reduction of age-dependent neuromelanin accumulation mitigates features of Parkinson's disease

Marta González-Sepúlveda, Joan Compte, Thaïs Cuadros…·Miquel Vila

This study reduces age-related neuromelanin accumulation in a humanized rodent model, mitigating Parkinson's disease features by preserving dopamine homeostasis and neuronal integrity.

38 citationstop 5%

ratexperimental assay

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