Author

Alba Nicolau

Biomedical Research Networking Center on Neurodegenerative DiseasesORCID 0000-0002-0836-2802Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Neuroscience· 4

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 3 Research Focus:differential expression· 2 Organism:mouse· 2 Organism:rat· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Organism:human· 1 Assay:metabolomics· 1

Frequent Co-Authors

Annabelle ParentiD· 4 shared Ariadna LagunaiD· 4 shared Marta González-SepúlvedaiD· 4 shared Miquel VilaiD· 4 shared Marina Lorente PicóniD· 3 shared Núria PeñuelasiD· 3 shared Camille Guillard-SirieixiD· 2 shared Helena XicoyiD· 2 shared

Activity by Year

2022-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 44 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

4 shared papersNeuroscience

Annabelle ParentORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Alpha-synuclein and neuromelanin converge to promote Parkinsons disease pathology

Alba Nicolau, Marta González-Sepúlveda, Joana M. Cladera-Sastre, Thais Cuadros, Annabelle Parent, Gerard Roch, Jacopo Marongiu, Benjamin Huynh, Anahid Ansari Mahabadian, Feifei Su, Zac Chatterton, Javier Hoyo, Ariadna Laguna, YuHong Fu, Glenda Margaret Halliday, Miquel Vila

This study identifies a bidirectional pathogenic relationship between alpha-synuclein and neuromelanin in Parkinson's disease, showing they promote each other's accumulation and neuronal loss.

bioRxiv · Oct 24, 2026 · PreprintNeuroscience

Age-dependent brain pigmentation drives early neuroinflammatory molecular signatures linked to neurodegeneration

Núria Peñuelas, Helena Xicoy, Marina Lorente Picón, Alba Nicolau, Annabelle Parent, Marta González-Sepúlveda, Ariadna Laguna, Miquel Vila

This study identifies age-dependent neuroinflammatory changes in NM-containing neurons linked to neurodegeneration, with GPNMB as a conserved protective factor in Parkinson's disease.

bioRxiv · Aug 7, 2026 · PreprintNeuroscience

Modelling human neuronal catecholaminergic pigmentation in rodents recapitulates age-related multisystem neurodegenerative deficits

Ariadna Laguna, Núria Peñuelas, Marta González-Sepúlveda, Alba Nicolau, Sébastien Arthaud, Camille Guillard-Sirieix, Marina Lorente Picón, Joan Compte, Lluís Miquel-Rio, Helena Xicoy, Jiong Liu, Annabelle Parent, Thais Cuadros, Jordi Romero‐Giménez, Gemma Pujol, , Miquel Vila

This paper creates a transgenic mouse model that mimics human neuromelanin accumulation in catecholaminergic neurons, leading to age-related neurodegenerative deficits.

Nature Communications · Oct 11, 2024Peer-reviewedNeuroscience

In vivo reduction of age-dependent neuromelanin accumulation mitigates features of Parkinson's disease

Marta González-Sepúlveda, Joan Compte, Thaïs Cuadros, Alba Nicolau, Camille Guillard-Sirieix, Núria Peñuelas, Marina Lorente Picón, Annabelle Parent, Jordi Romero‐Giménez, Joana M. Cladera-Sastre, Ariadna Laguna, Miquel Vila

This study reduces age-related neuromelanin accumulation in a humanized rodent model, mitigating Parkinson's disease features by preserving dopamine homeostasis and neuronal integrity.

Brain · Nov 23, 2022Peer-reviewedNeuroscience