Author

Brooke R. D’Arcy

Duke UniversityORCID 0000-0002-1576-3487Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 4 Approach:experimental assay· 4 Organism:mouse· 4 Research Focus:gene regulatory network inference· 2 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1 Research Focus:clustering· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Debra L. SilveriD· 4 shared Camila Manso MussoiD· 2 shared Stephany Perez-Sanchez· 2 shared Alex S Nord· 1 shared Annalise Bracher· 1 shared Ashley L. Lennox· 1 shared Bonnie Taylor‐BlakeiD· 1 shared Carla Escobar-Tomlienovich· 1 shared

Activity by Year

2022-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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4 shared papersNeuroscience

Debra L. SilverORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Chd8 haploinsufficiency leads to molecular layer heterotopias and age-dependent cortical expansion

Felix A. Kyere, Ian Curtin, Ziquan Wei, César P. Canales, Nicolas Seban, Lei Xing, Preslava P Todorova, Leticia Pérez-Sisqués, Maya Yilan Yin, Tao Wen, Roza Vlasova, Dirgha Sheth, Jeffrey Bennett, Kejia Li, Nana Matoba, , Jason L. Stein

This study identifies molecular layer heterotopias and age-dependent cortical expansion in Chd8 haploinsufficient mice, linking them to neuronal migration defects and autism-related brain overgrowth.

bioRxiv · Jun 22, 2026 · PreprintNeuroscience

Dissecting mammalian cortical circuit development at single-cell resolution using inducible barcoded rabies virus

Zijian Zhang, Brooke R. D’Arcy, Lewei He, Diego Arroyo, Samantha Deasy, Elizabeth A. Matthews, Zihan Yan, Nirvika Rastogi, Walter Mancia Leon, Kiran Shehnaz Kaur, Derek G. Southwell, Z. Josh Huang, Debra L. Silver, Dmitry Velmeshev

The paper develops an inducible barcoded rabies virus to study neuronal circuit development at single-cell and spatial resolution in mice, revealing developmental connectivity patterns and constructing in silico circuit models.

bioRxiv · Nov 7, 2025 · PreprintNeuroscience

Subcellular transcriptome of radial glia reveals compartmentalized control of cortical development

Brooke R. D’Arcy, Camila Manso Musso, Chia-Fang Lee, Lucas D. Serdar, Stephany Perez-Sanchez, Virginia Fernández, Vı́ctor Borrell, Debra L. Silver

The paper identifies a subcellular transcriptome in radial glia, revealing localized gene regulation and its role in cortical development.

bioRxiv · Oct 10, 2025 · PreprintNeuroscience

Subcellular proteome of radial glia reveals non-muscle myosins control basal endfeet to mediate interneuron organization

Brooke R. D’Arcy, Ashley L. Lennox, Camila Manso Musso, Annalise Bracher, Carla F. Escobar-Tomlienovich, Stephany Perez-Sanchez, Debra L. Silver

The paper uses in vivo proximity labeling to analyze the subcellular proteome of radial glial cells and identifies non-muscle myosins that regulate endfoot structure and interneuron organization.

bioRxiv · Nov 18, 2022 · PreprintNeuroscience